Home > The Hidden Story of Cancer > Parent to Derivative EFA Ratios – The conversion is MUCH LESS than Everyone States

Parent to Derivative EFA Ratios – The conversion is MUCH LESS than Everyone States

The major metabolic route of ALA (parent omega-3) in the body is beta-oxidation. This means that parent omega-3 is mainly burned for energy – not incorporated into cellular structure or used for derivatives – your body requires very little and will attempt to remove an excess if it can. ONLY VERY LITTLE PARENT OMEGA-3 IS REQUIRED FOR PROPER CELL MEMBRANE STRUCTURE. However, if you are “overdosing” from supplements, based on incorrect advice [which is MOST of the current advice on the market], the excess will be forced into the cell structure as the “Lipids 2000” medical journal states:

“Linoleic acid (LA parent omega-6 FA) accumulates throughout the body of most mammals, whereas alpha-linolenic acid [ALA parent omega-3] is rarely found in those tissues to the same extent as LA”, “Increased alpha-linolenic acid [parent omega-3] intake increases tissue alpha-linolenic content [parent omega-3]” (Lipids 2000 Apr; 35(4):395-400.

This will NEGATIVELY IMPACT your cancer defense.

ALA accumultes in specific sites in the body of mammals, and only a small portion of dietary ALA is converted to DHA (Sinclair, A.J., et al., “What is the role of alpha-linolenic acid for mammals,” Lipids 2002 Dec;37(12):113-23).

The next piece of shocking information is from the “PUFA Newsletter”. “Alpha-Linolenic Acid Conversion Revisted” by Norman Salem et al., states,

“A recent article in the PUFA [Polyunsaturated Fatty Acid] Newsletter indicated that in adult men and women the ‘average estimated conversion of … alpha-linolenic acid to n-3-LC-PUFA metabolites and docosahexaenoic acid [DHA] was 17.3 +/- 12.8 and 3.6 +/- 3.8 percent, respectively (mean + SD)’. This is likely to be an OVERESTIMATE of the actual overall conversion rates for several reasons. We see even with this excessive estimate of the parent omega-3 derivative conersion that theoretically no more than 37% of them are converted to derivatives.”

The article makes the case that in reality only about 5% of the parent ALA [omega-]) is converted into derivatives. Pawlosky and others calculate that less than a mere 1% goes to derivatives. The article ends with, “The best estimates of alpha-linolenic acid conversion to n-3 LC-PUFA are much smaller than those claimed…”

Omega-6 conversion is also overstated:

“… Linking LA and AA in this way also implies a direct conversion of LA [parent omega-6] to AA [omega-6 derivative] which is not the case. In fact, a very high dietary LA will reduce membrane AA [the opposite effect!].” Note: This is why it was reported in the article by S. Bunting, s. Moncada, and J.R. Vane, titled “Prostacyclin – Thromboxane A2 Balance: Pathophysiological and Terapeutic Implications,” ‘British Medical Journal’, (1983)Vo.39, No.3, pages 271-276, that “AA in the phospholipids of Eskimo [consuming lots of parent omega-6] is approximately ONE-THIRD of that in Danes.”

The above quote was taken from Crawford, M.A., “Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids,” in ‘Prostaglandins Leukot Essent Fatty acids 2000 Sep;63(3):131-4.

Here is the takehome to all the science above:

TOO MUCH OMEGA-3, OMEGA DERIVATIVES, OR DEFECTIVE EFAS RUIN THE CELL MEMBRANE STRUCTURE AND MINIMIZE YOUR LEVEL OF ANTICANCER PROTECTION.

Remember your goal is to MAXIMIZE the cell membrane structure so that the cells can remain fully oxygenated (cellular oxygenation), thus preventing a drop in cellular oxygenation of 30% which is the threshhold that Dr. Otto Warburg showed over and over again that healthy cells convert to cancer cells and cannot be reconverted.

So… when you are supplementing with Parent Essential Oils, PLEASE be sure you find a blend with the PROPER balance of Omega-6 and Omega-3 (2.5:1 to 1:1) or you could inevitably be negatively affecting your health and cancer prevention.

You can read more about this in much more detail in my book, “The Hidden Story of Cancer”, which can be ordered through the following website: http://www.brianpeskin.com.

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